Recombinant vesicular stomatitis virus as an HIV-1 vaccine vector
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چکیده
منابع مشابه
Evaluating replication-defective vesicular stomatitis virus as a vaccine vehicle.
We have generated replication-competent (VSV-C/E1/E2) and nonpropagating (VSVDeltaG-C/E1/E2) vesicular stomatitis virus (VSV) contiguously expressing the structural proteins of hepatitis C virus (HCV; core [C] and glycoproteins E1 and E2) and report on their immunogenicity in murine models. VSV-C/E1/E2 and VSVDeltaG-C/E1/E2 expressed high levels of HCV C, E1, and E2, which were authentically po...
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Acute Pathogenesis of Recombinant Vesicular Stomatitis Virus Vaccine Vectors is Linked to Interleukin-1 by Kathleen Constance Athearn Department of Pathology Duke University Date:_______________________ Approved: ___________________________ Elizabeth Ramsburg, Supervisor ___________________________ Herman Staats ___________________________ David Pickup An abstract of a thesis submitted in parti...
متن کاملAttenuated vesicular stomatitis viruses as vaccine vectors.
We showed previously that a single intranasal vaccination of mice with a recombinant vesicular stomatitis virus (VSV) expressing an influenza virus hemagglutinin (HA) protein provided complete protection from lethal challenge with influenza virus (A. Roberts, E. Kretzschmar, A. S. Perkins, J. Forman, R. Price, L. Buonocore, Y. Kawaoka, and J. K. Rose, J. Virol. 72:4704-4711, 1998). Because some...
متن کاملRecombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein.
A recombinant S segment RNA (Sr) of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) where the glycoprotein of vesicular stomatitis virus (VSVG) was substituted for the glycoprotein of LCMV (LCMV-GP) was produced intracellularly from cDNA under the control of a polymerase I promoter. Coexpression of the LCMV proteins NP and L allowed expression of VSVG from Sr. Infection of t...
متن کاملGeneration of hepatitis C virus-like particles by use of a recombinant vesicular stomatitis virus vector.
Hepatitis C virus (HCV), a major etiologic agent of hepatocellular carcinoma, presently infects approximately 400 million people worldwide, making the development of protective measures against HCV infection a key objective. Here we have generated a recombinant vesicular stomatitis virus (VSV), which expresses the HCV structural proteins, by inserting the contiguous Core, E1, and E2 coding regi...
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ژورنال
عنوان ژورنال: Springer Seminars in Immunopathology
سال: 2006
ISSN: 0344-4325,1432-2196
DOI: 10.1007/s00281-006-0042-3